Study identifier:D7860C00003
ClinicalTrials.gov identifier:NCT06368440
EudraCT identifier:N/A
CTIS identifier:N/A
A Single-blind, Randomized, Placebo-controlled Study to Investigate the Safety, Tolerability and Pharmacokinetics of an oral suspension of AZD6793 Following Single and Multiple Doses in Japanese and Chinese Healthy Participants
Healthy Participants
Phase 1
Yes
AZD6793, Placebo
All
40
Interventional
18 Years - 55 Years
Allocation: Randomized
Endpoint Classification: -
Intervention Model: Sequential Assignment
Masking: -
Primary Purpose: Other
Verified 01 Nov 2024 by AstraZeneca
AstraZeneca
-
No locations available
Arms | Assigned Interventions |
---|---|
Experimental: Part 1: Cohort 1 AZD6793 6 Healthy Japanese participants will receive single dose of AZD6793 dose 1 and 2 healthy Japanese participants will receive matching placebo to AZD6793 as oral suspension on Day 1. | Drug: AZD6793 Participants will receive AZD6793 single dose as oral suspension. Drug: Placebo Participants will receive matching doses of placebo as oral suspension. |
Experimental: Part 1: Cohort 2 AZD6793 6 Healthy Japanese participants will receive single dose of AZD6793 dose 2 and 2 healthy Japanese participants will receive matching placebo to AZD6793 as oral suspension on Day 1. | Drug: AZD6793 Participants will receive AZD6793 single dose as oral suspension. Drug: Placebo Participants will receive matching doses of placebo as oral suspension. |
Experimental: Part 1: Cohort 3 AZD6793 6 Healthy Chinese participants will receive single dose of AZD6793 dose 1 and 2 healthy Chinese participants will receive matching placebo to AZD6793 as oral suspension on Day 1. | Drug: AZD6793 Participants will receive AZD6793 single dose as oral suspension. Drug: Placebo Participants will receive matching doses of placebo as oral suspension. |
Experimental: Part 2: Cohort 1 AZD6793 6 Japanese participants will receive single dose of AZD6793 and 2 participants will receive matching placebo on Day 1. After a washout of at least 48 hours, participants will receive AZD6793 or placebo once daily from Day 3 to Day 8. | Drug: AZD6793 Participants will receive AZD6793 multiple doses daily as oral suspension. Drug: Placebo Participants will receive matching doses of placebo as oral suspension. |
Experimental: Part 2: Cohort 2 AZD6793 6 Chinese participants will receive single dose of AZD6793 and 2 participants will receive matching placebo on Day 1. After a washout of at least 48 hours, participants will receive AZD6793 or placebo once daily from Day 3 to Day 8. | Drug: AZD6793 Participants will receive AZD6793 multiple doses daily as oral suspension. Drug: Placebo Participants will receive matching doses of placebo as oral suspension. |