A Study Designed to Assess the Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD5462 and the Absolute Bioavailability of AZD5462

Exclusion Criteria

• - History of any clinically significant disease or disorder
• - History or presence of clinically significant gastrointestinal, hepatic or renal disease, or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs
• - History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity
• - History of active malignancy within 2 years, or under investigation for any form of cancer
• - Participants who do not have suitable veins for multiple venepunctures/cannulation
• - Clinically significant abnormal clinical chemistry, haematology or urinalysis
• - Any clinically significant abnormalities in vital signs
• - Any clinically significant abnormalities on 12-lead ECG
• - Abnormal renal function
• - Radiation exposure exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years, occupationally exposed worker, or have been administered IMP in a radiolabelled ADME study in the last 12 months.
• - Use of any prescribed or non-prescribed medication including antacids, analgesics, herbal remedies, vitamins and minerals
• - Current smokers or known or suspected history of alcohol or drug abuse
• - Excessive intake of caffeine-containing drinks or food